The paper1 categorizes levels of evidence for comparison of drugs within a class from 1-4, each with unique threats to validity. Levels 3 and 4 will be discussed later. Superiority …
It is understood, broadly speaking, that drugs of the same class confer the same merits/risks, though one may be more efficacious and safer than the other. The drug class paper …
Surrogate endpoints are endpoints that are not directly related to the clinical outcome of interest but are used as a substitute for it. They are often used in clinical trials to …
There’s a series from JAMA that goes over how to read clinical trials. The series is written by individuals who are widely recognized in the field of evidence-based medicine. …
Sham surgeries are procedures that mimic real surgeries but do not include the critical therapeutic component. They are often used in clinical trials to serve as one of the …
So far I’ve subscribed to a couple journals and some blogs. Here’s a partial list: CDC MMWR Phase 3 and 4 clinical trials from: BMJ NEJM The Lancet Blogs from: Sensible …
What follows is an argument for the more liberal forms of the SPICES model of medical education1. The paper itself is relatively old, but many medical schools, especially in the …
Robbins pathology1 and GH medical physiology2 IntroductionType 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by the destruction of beta cells, leaving patients …