The paper1 categorizes levels of evidence for comparison of drugs within a class from 1-4, each with unique threats to validity. Levels 3 and 4 will be discussed later. Superiority …
It is understood, broadly speaking, that drugs of the same class confer the same merits/risks, though one may be more efficacious and safer than the other. The drug class paper …
Surrogate endpoints are endpoints that are not directly related to the clinical outcome of interest but are used as a substitute for it. They are often used in clinical trials to …
There’s a series from JAMA that goes over how to read clinical trials. The series is written by individuals who are widely recognized in the field of evidence-based medicine. …