Soliloquy of the Nameless
The rail separates the pine grove steeped in haze from the serene lake, which stretches to the base of a mountain barely visible beyond the winter haze, the apparition of a white …
17 min
Stories
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24 posts and 17,697 words published in the last year
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Founders of EBM
When reading papers and textbooks, the following figures appear most repeatedly. SackettSackett was one of the founders of EBM. Contributions include several seminal RCTs showing …
3 min
Lessons from Basic Statistics for Clinician: Hypothesis Testing
Uncertainty comes with a study of modest power (too small a sample size to rule out chance)—one that does not produce a result below the 0.05 significance threshold but may still, …
2 min
Pharmaceutical Companies and Misleading Claims in the Literature
I remember reading somewhere—I forget where—that these companies will often publish their material in-house (i.e. rather than going to an independent, well-established journal, …
2 min
Medicine
Grading Drugs Within a Class: Level 1-2 of Evidence
The paper1 categorizes levels of evidence for comparison of drugs within a class from 1-4, each with unique threats to validity. Levels 3 and 4 will be discussed later. Superiority …
3 min
Medicine
JAMA Literature Series
Assuming the Drug Class Effect
It is understood, broadly speaking, that drugs of the same class confer the same merits/risks, though one may be more efficacious and safer than the other. The drug class paper …
2 min
Medicine
JAMA Literature Series